Using the SCN Vibrational Probe Group to Determine the Membrane-Bound Structural Distribution of N-Terminally Acetylated Alpha-Synuclein
نویسندگان
چکیده
منابع مشابه
Copper binding to the N-terminally acetylated, naturally occurring form of alpha-synuclein induces local helical folding.
Growing evidence supports a link between brain copper homeostasis, the formation of alpha-synuclein (AS)-copper complexes, and the development of Parkinson disease (PD). Recently it was demonstrated that the physiological form of AS is N-terminally acetylated (AcAS). Here we used NMR spectroscopy to structurally characterize the interaction between Cu(I) and AcAS. We found that the formation of...
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15 صفحه اولMembrane-bound structure and energetics of alpha-synuclein.
Aggregation and fibrillation of alpha-synuclein bound to membranes are believed to be involved in Parkinson's and other neurodegenerative diseases. On SDS micelles, the N-terminus of alpha-synuclein forms two curved helices linked by a short loop. However, its structure on lipid bilayers has not been experimentally resolved. Using MD simulations with an implicit membrane model we show here that...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2016.11.1981